| | | Monday, October 3rd, 2011 | | Released MR T. Seaton. |
| Wednesday, September 28th, 2011 | | Activated RF S. Collins from the disabled list. |
| Tuesday, September 13th, 2011 | | Signed free agent MR M. Garza to a 1-year contract worth a total of $145,000. |
| Saturday, September 3rd, 2011 | | Placed RF S. Collins on the 15-day disabled list. |
| Sunday, August 7th, 2011 | | Activated SS O. Krueger from the disabled list. |
| Saturday, July 23rd, 2011 | | Placed SS O. Krueger on the 15-day disabled list. |
| Friday, May 27th, 2011 | | Activated MR J. Tannehill from the 60-day disabled list. |
| Thursday, May 19th, 2011 | | Placed SP C. Capuano on the 15-day disabled list. |
| Friday, April 8th, 2011 | | Activated RF N. McLouth from the disabled list. |
| Monday, March 28th, 2011 | | Signed free agent MR T. Seaton to a minor league contract. |
| Thursday, March 24th, 2011 | | Placed RF N. McLouth on the 15-day disabled list. |
| Thursday, March 17th, 2011 | | Placed MR J. Tannehill on the 60-day disabled list. |
| Sunday, March 6th, 2011 | | Activated RF S. Collins from the disabled list. |
| Friday, February 11th, 2011 | | Placed RF S. Collins on the 15-day disabled list. |
| Wednesday, November 17th, 2010 | | Signed hitting coach R. Martínez to a 1-year, $45,000 per year contract. |
| Monday, November 15th, 2010 | | Drafted LF D. Wakefield in the 2010 first-year player draft (Round 1, Pick 7, 7th overall Pick). | | Drafted LF D. Litwhiler in the 2010 first-year player draft (Round 2, Pick 7, 23rd overall Pick). | | Drafted C W. Cooper in the 2010 first-year player draft (Round 3, Pick 7, 39th overall Pick). | | Drafted SP H. Wyse in the 2010 first-year player draft (Round 4, Pick 7, 55th overall Pick). | | Drafted C J. Hegan in the 2010 first-year player draft (Round 5, Pick 7, 71st overall Pick). |
| Monday, November 8th, 2010 | | CF O. Charleston received a 1-year contract through automatic renewal worth a total of $131,565. | | SP T. Lincecum received a 1-year contract through automatic renewal worth a total of $131,565. | | 1B C. Anson received a 1-year contract through automatic renewal worth a total of $131,565. | | SP L. Baldwin received a 1-year contract through automatic renewal worth a total of $131,565. | | C D. White received a 1-year contract through automatic renewal worth a total of $131,565. | | 2B C. Childs received a 1-year contract through automatic renewal worth a total of $131,565. | | SP J. Tannehill received a 1-year contract through automatic renewal worth a total of $131,565. | | LF R. Braun received a 1-year contract through automatic renewal worth a total of $131,565. | | MR G. Sherrill received a 1-year contract through automatic renewal worth a total of $131,565. | | MR D. McBride received a 1-year contract through automatic renewal worth a total of $131,565. | | CL M. MacDougal received a 1-year contract through automatic renewal worth a total of $131,565. | | MR D. Nippert received a 1-year contract through automatic renewal worth a total of $131,565. | | RF I. Suzuki received a 1-year contract through automatic renewal worth a total of $131,565. | | SP S. McMahon received a 1-year contract through automatic renewal worth a total of $131,565. | | 1B S. Thomas received a 1-year contract through automatic renewal worth a total of $420,000. | | 1B K. Youkilis received a 1-year contract through automatic renewal worth a total of $131,565. | | LF C. Quentin received a 1-year contract through automatic renewal worth a total of $131,565. | | RF N. McLouth received a 1-year contract through automatic renewal worth a total of $131,565. | | 3B G. Atkins received a 1-year contract through automatic renewal worth a total of $131,565. | | 3B T. Wigginton received a 1-year contract through automatic renewal worth a total of $131,565. | | C M. Montero received a 1-year contract through automatic renewal worth a total of $131,565. | | SP C. Capuano received a 1-year contract through automatic renewal worth a total of $131,565. | | LF D. Lewis received a 1-year contract through automatic renewal worth a total of $131,565. | | RF S. Collins received a 1-year contract through automatic renewal worth a total of $131,565. | | SS O. Krueger received a 1-year contract through automatic renewal worth a total of $131,565. | | Activated LF R. Braun from the disabled list. | | Released 1B B. Broussard. |
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