| | | Thursday, September 22nd, 2011 | | Activated SP V. Willis from the 60-day disabled list. |
| Sunday, September 18th, 2011 | | Placed SP B. Zito on the 60-day disabled list. |
| Sunday, July 24th, 2011 | | Placed SP V. Willis on the 60-day disabled list. |
| Wednesday, June 15th, 2011 | | Signed free agent MR E. Santana to a minor league contract. | | Released MR E. Santana. |
| Friday, May 13th, 2011 | | Activated SS J. Rollins from the disabled list. |
| Sunday, May 8th, 2011 | | Activated LF T. Strong from the disabled list. |
| Monday, April 25th, 2011 | | Activated RF M. Tiernan from the disabled list. |
| Wednesday, April 13th, 2011 | | Placed SS J. Rollins on the 15-day disabled list. |
| Monday, April 11th, 2011 | | Placed LF T. Strong on the 15-day disabled list. |
| Friday, April 8th, 2011 | | Placed RF M. Tiernan on the 15-day disabled list. |
| Sunday, April 3rd, 2011 | | Activated 3B A. Radcliffe from the 60-day disabled list. | | Signed free agent 2B F. Sanchez to a minor league contract. |
| Sunday, March 13th, 2011 | | Placed MR B. Dinneen on the 60-day disabled list. |
| Saturday, March 5th, 2011 | | Signed free agent SS B. Weaver to a minor league contract. | | Signed free agent CF J. Pierre to a minor league contract. |
| Wednesday, February 2nd, 2011 | | Placed 3B A. Radcliffe on the 60-day disabled list. |
| Friday, January 14th, 2011 | | Released MR D. Turnbow. |
| Thursday, January 13th, 2011 | | Signed free agent MR D. Turnbow to a minor league contract. |
| Saturday, January 8th, 2011 | | Signed free agent C R. Lamanno to a 2-year contract worth a total of $1,010,000. | | Released MR C. Vargas. |
| Thursday, January 6th, 2011 | | Signed free agent MR D. Turnbow to a minor league contract. |
| Tuesday, December 21st, 2010 | | Signed free agent 2B J. Cantu to a 2-year contract worth a total of $370,000. | | Released MR C. Young. |
| Saturday, December 11th, 2010 | | Signed free agent 3B J. Collins to a 2-year contract worth a total of $370,000. | | Released MR G. Haddock. |
| Monday, November 15th, 2010 | | Drafted LF T. Strong in the 2010 first-year player draft (Round 1, Pick 2, 2nd overall Pick). | | Drafted SP W. Spahn in the 2010 first-year player draft (Round 2, Pick 2, 18th overall Pick). | | Drafted SP V. Trucks in the 2010 first-year player draft (Round 3, Pick 2, 34th overall Pick). | | Drafted SP J. Nuxhall in the 2010 first-year player draft (Round 4, Pick 2, 50th overall Pick). | | Drafted SP O. Judd in the 2010 first-year player draft (Round 5, Pick 2, 66th overall Pick). |
| Monday, November 8th, 2010 | | SP J. Corbett received a 1-year contract through automatic renewal worth a total of $131,565. | | RF M. Tiernan received a 1-year contract through automatic renewal worth a total of $131,565. | | LF E. Delahanty received a 1-year contract through automatic renewal worth a total of $131,565. | | CF G. Van Haltren received a 1-year contract through automatic renewal worth a total of $131,565. | | SP V. Willis received a 1-year contract through automatic renewal worth a total of $131,565. | | C J. Mauer received a 1-year contract through automatic renewal worth a total of $131,565. | | CL B. Donnelly received a 1-year contract through automatic renewal worth a total of $131,565. | | MR G. Weyhing received a 1-year contract through automatic renewal worth a total of $131,565. | | 2B B. Lowe received a 1-year contract through automatic renewal worth a total of $131,565. | | SS J. Rollins received a 1-year contract through automatic renewal worth a total of $131,565. | | 3B B. Bradley received a 1-year contract through automatic renewal worth a total of $131,565. | | MR D. Slaten received a 1-year contract through automatic renewal worth a total of $131,565. | | MR J. Lackey received a 1-year contract through automatic renewal worth a total of $131,565. | | C D. Navarro received a 1-year contract through automatic renewal worth a total of $131,565. | | SP C. Sabathia received a 1-year contract through automatic renewal worth a total of $131,565. | | 1B M. Jacobs received a 1-year contract through automatic renewal worth a total of $131,565. | | 1B N. Swisher received a 1-year contract through automatic renewal worth a total of $131,565. | | 2B D. Uggla received a 1-year contract through automatic renewal worth a total of $131,565. | | SP D. Haren received a 1-year contract through automatic renewal worth a total of $131,565. | | SP B. Zito received a 1-year contract through automatic renewal worth a total of $131,565. | | 3B A. Radcliffe received a 1-year contract through automatic renewal worth a total of $131,565. | | LF A. Leonard received a 1-year contract through automatic renewal worth a total of $131,565. | | LF K. Mench received a 1-year contract through automatic renewal worth a total of $131,565. | | 2B J. Baker received a 1-year contract through automatic renewal worth a total of $131,565. |
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